Protein Misfolding and Aggregation in Neurodegenerative Disorders: Focus on Chaperone-Mediated Protein Folding Machinery

Proteins are delicate, versatile and structurally complex biomolecules which regulate fundamental processes of the cellular systems. They are synthesized as long stretches of amino acid chains and in order to achieve the functional state each polypeptide chain must be folded into unique 3-dimensional structure [1] . However, proteins have a very narrow range of thermodynamically stable physiologic…