4-1BB is Superior to CD28 Costimulation for Generating Effec…
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- DOI 10.4049/jimmunol.178.supp.48.12
- OpenAlex ID W127299780
- Type Article
- Language EN
- Published 01 Apr 2007
- Volume 178 (1_Supplement)
- Pages S76–S77
- Source The Journal of Immunology
- Publisher American Association of Immunologis…
- Countries 1
- Institutions 3
- Added 24 Jun 2016
- Updated 16 Oct 2026
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4-1BB is Superior to CD28 Costimulation for Generating Effector CD8+ T Cells for Adoptive Immunotherapy (48.12)
Article 2007 EN
Abstract Artificial APCs (aAPCs) provide a new approach to expand cells for adoptive cell therapy, but optimal requirements for CD8+ expansion have not been defined. Beads expressing αCD3/αCD28 efficiently expand CD4+ cells, but not cytolytic CD8+ T cells. 4-1BB, a costimulatory molecule expressed by a minority of resting CD8+ T cells, is transiently upregulated by all CD8+ T cells following activ…
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UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
7 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | hua zhang | National Institutes of Health (US) National Cancer Institute (US) | — |
| 2 | Kristen Snyder | National Institutes of Health (US) National Cancer Institute (US) | — |
| 3 | Megan M. Suhoski | University of Pennsylvania (US) | |
| 4 | Marcela Valderrama Maus | University of Pennsylvania (US) | |
| 5 | Veena Kapoor | National Institutes of Health (US) National Cancer Institute (US) | — |
| 6 | Carl H. June | University of Pennsylvania (US) | |
| 7 | Crystal Lee Mackall | National Institutes of Health (US) National Cancer Institute (US) |
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