Mitochondrial Dysfunction in the Pathogenesis of Acute Neural Cell Death

Now that the involvement of mitochondrial dysfunction in both necrotic and apoptotic neuronal cell death is firmly established, the molecular mechanisms by which acute stress alters mitochondrial activities and induces cell death must be elucidated. Although a greater understanding of mitochondrial ROS production and apoptogenic protein release is essential, we should also continue to study the wa…